alexa Searching for genetic determinants in the new millennium.
Mathematics

Mathematics

Journal of Biometrics & Biostatistics

Author(s): Risch NJ

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Abstract Human genetics is now at a critical juncture. The molecular methods used successfully to identify the genes underlying rare mendelian syndromes are failing to find the numerous genes causing more common, familial, non-mendelian diseases. With the human genome sequence nearing completion, new opportunities are being presented for unravelling the complex genetic basis of non-mendelian disorders based on large-scale genome-wide studies. Considerable debate has arisen regarding the best approach to take. In this review I discuss these issues, together with suggestions for optimal post-genome strategies. This article was published in Nature and referenced in Journal of Biometrics & Biostatistics

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