alexa Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps.
Microbiology

Microbiology

Journal of Antimicrobial Agents

Author(s): Bohnert JA, Kern WV

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Abstract Several arylpiperazines capable of reversing multidrug resistance (MDR) in Escherichia coli overexpressing acrAB and acrEF but not in pump-deficient mutant strains were identified. 1-(1-Naphthylmethyl)-piperazine, one of the more active compounds, enhanced susceptibility to fluoroquinolones and other agents and increased the intracellular concentration of levofloxacin and ethidium bromide, suggesting efflux pump inhibition as the mechanism of MDR reversal.
This article was published in Antimicrob Agents Chemother and referenced in Journal of Antimicrobial Agents

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