alexa Selecting optimal oligonucleotide primers for multiplex PCR.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Computer Science & Systems Biology

Author(s): Nicodme P, Steyaert JM

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Abstract We investigate the problem of designing efficient multiplex PCR for medical applications. We show that the problem is NP-complete by transformation to the Multiple Choice Matching problem and give an efficient approximation algorithm. We developed this algorithm in a computer program that predicts which genomic regions may be simultaneously amplified by PCR. Practical use of the software shows that the method can treat 250 non-polymorphic loci with less than 5 simultaneous experiments.
This article was published in Proc Int Conf Intell Syst Mol Biol and referenced in Journal of Computer Science & Systems Biology

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