alexa Selective Loss of S-Cones in Diabetic Retinopathy
Ophthalmology

Ophthalmology

Journal of Clinical & Experimental Ophthalmology

Author(s): Cho NC, Poulsen GL, Ver Hoeve JN, Nork TM

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Objective To determine whether selective cone loss could explain the acquired tritan-like color confusion found in diabetic retinopathy. Methods Terminal deoxynucleotidyl transferase–mediated biotin-deoxyuridine triphosphate nick end labeling (TUNEL) was employed on paraffin sections of retinas from 5 donors with diabetic retinopathy. For quantitative analysis, postmortem retinas were obtained from 13 human donors; 7 from patients with various durations and stages of diabetic retinopathy (4 background, 3 proliferative) and 6 controls. Enzyme histochemical analysis for carbonic anhydrase (CA) was used to distinguish L/M-cones (positive for CA) from S-cones (negative for CA). Cone topography was determined by sampling 360° from 0.1 to 1.5 mm of foveal eccentricity and along the horizontal meridians from 1.5 to 15.0 mm. Results Rare cells in both the inner and outer nuclear layers of the diabetic eyes were positively labeled with the TUNEL method. The CA staining revealed incomplete and patchy losses of S-cones that were limited to the diabetic retinas. Statistically significant reduction in the density of S-cones was found at nearly all foveal eccentricities from 0.1 mm to 15.0 mm. This was not the case for the L/M-cones. On average, for all locations, the percentage of S-cones compared with L/M-cones was decreased by 21.0% ± 3.4% with respect to the controls. Conclusion The S-cones selectively die in diabetic retinopathy.

This article was published in Archives of ophthalmology and referenced in Journal of Clinical & Experimental Ophthalmology

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