alexa Selenium: biochemical role as a component of glutathione peroxidase.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Diabetes & Metabolism

Author(s): Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG

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When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H(2)O(2), added glutathione failed to protect the hemoglobin from oxidative damage. This occurred because the erythrocytes were practically devoid of glutathione-peroxidase activity. Extensively purified preparations of glutathione peroxidase contained a large part of the (75)Se of erythrocytes labeled in vivo. Many of the nutritional effects of selenium can be explained by its role in glutathione peroxidase.

This article was published in Science. and referenced in Journal of Diabetes & Metabolism

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