alexa Semen characteristics and sperm DNA fragmentation in infertile men with low and high levels of seminal reactive oxygen species.
Reproductive Medicine

Reproductive Medicine

Andrology-Open Access

Author(s): Mahfouz R, Sharma R, Thiyagarajan A, Kale V, Gupta S,

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Abstract OBJECTIVE: To examine sperm motility, total antioxidant level (TAC), DNA fragmentation, and medical history in infertile men with high seminal high reactive oxygen species (ROS). DESIGN: Prospective study. SETTING(S): Tertiary care hospital. PATIENT(S): Infertile men (n=101). INTERVENTION(S): Group I (n=57) included men with seminal ROS (<250 relative light units/sec/×10(6) sperm) while group II (n=44) included men with seminal ROS levels (≥250 relative light units/sec/×10(6) sperm). MAIN OUTCOME MEASURE(S): Seminal ROS, TAC, sperm DNA fragmentation, ROS/TAC score were measured. RESULT(S): Group II had a high incidence of sperm DNA fragmentation than group I. The odds ratio of 1.25 for elevated ROS levels corresponded to >10\% greater DNA fragmentation in our patients (95\% confidence interval 1.01-1.53). Group II showed poor motility, a higher incidence of leukocytospermia, and higher ROS-TAC scores compared with group I. ROS was negatively correlated with sperm curvilinear velocity (r=-.24), linearity (r=-.24), and sperm motility (r=-.31). Sperm motility was correlated with \%TUNEL(+ve) sperm (r=-.39). CONCLUSION(S): An increase in seminal ROS levels by 25\% was associated with a 10\% increase in sperm DNA fragmentation. Sperm motility was affected by seminal ROS and sperm DNA fragmentation. Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. This article was published in Fertil Steril and referenced in Andrology-Open Access

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