alexa Semi-quantitative expression of tissue inhibitor of matrix metalloproteinase-2 in cancer of uterine cervix.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Wu YC, Wang PH, Tsai A, Yang SF, Chen SC

Abstract Share this page

Abstract BACKGROUND AND OBJECTIVE: Because matrix metalloproteinase-2 (MMP-2) is associated with tumor progression and tissue inhibitor of MMP-2 (TIMP-2) selectively inhibits MMP-2, we investigate the implication of TIMP-2 in carcinogenesis of uterine cervix. METHODS: Twenty-six cervical cancer tissues and their normal counterparts were collected to evaluate semi-quantitative mRNA expression of TIMP-2. Eighty-two cervical cancer, 26 high-grade and 26 low-grade dysplasia, and 26 normal tissues were collected to construct tissue microarrays for immunohistochemical study. We evaluated TIMP-2 immunoreactivity using H scores in cervical carcinogenesis. Semi-quantitative expression of MMP-2 was also detected for comparison. RESULTS: Cervical cancer tissues exhibited statistically lower semi-quantitative TIMP-2 (P = 0.028) or higher MMP-2 (P = 0.036) mRNA expression than their normal counterparts. None of cervical cancer tissues exerted elevated TIMP-2 and reduced MMP-2 mRNA expression simultaneously. Cancer tissues have significantly lower TIMP-2 or higher MMP-2 H scores than high-grade and low-grade dysplasia or normal tissues of uterine cervix. CONCLUSIONS: Low expression of TIMP-2 or high expression of MMP-2 is semi-quantitatively demonstrated in cancer of uterine cervix. TIMP-2 is implicated in cervical carcinogenesis. Copyright © 2011 Wiley-Liss, Inc. This article was published in J Surg Oncol and referenced in Journal of Cytology & Histology

Relevant Expert PPTs

Relevant Speaker PPTs

  • Ji-Zhong Bai
    Astrocytic contribution to deficient Ca2+ signalling and oxidative stress mediated by TRPV4 channels in A40-induced hippocampal cell death
    PPT Version | PDF Version
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version