alexa Septic pulmonary embolism: presenting features and clinical course of 14 patients.
Medicine

Medicine

Otolaryngology: Open Access

Author(s): Cook RJ, Ashton RW, Aughenbaugh GL, Ryu JH

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Abstract BACKGROUND: Septic pulmonary embolism (SPE) is an uncommon disorder with an insidious onset and is difficult to diagnose. STUDY OBJECTIVES: To characterize the presenting features and clinical course of patients with SPE. DESIGN: Retrospective study. SETTING: Tertiary care, referral medical center. PATIENTS: Fourteen subjects with SPE diagnosed during a 6-year period between 1996 and 2002. INTERVENTIONS: None. RESULTS: The median age of these patients was 37.5 years (range, 14 to 81 years) and included five women. Presenting symptoms included fever (93\%), dyspnea (36\%), pleuritic chest pain (29\%), cough (14\%), and hemoptysis (7\%). The median duration of symptoms before diagnosis was 18 days (range, 5 to 180 days). A potential source or underlying condition that predisposed to SPE was identified in all 14 patients and included Lemierre syndrome (4 patients), central venous catheter infection (3 patients), prosthetic cardiac valve (2 patients), and pacemaker infection (2 patients). Two patients had a focal extrapulmonary infection, and one patient was an IV drug user. Most common pathogens were staphylococcal species (eight patients) and fusobacterium (four patients). Chest radiographic presentation was usually nonspecific, but CT was more helpful and revealed multiple nodular opacities peripherally, often with cavitation. Transesophageal echocardiography was performed in eight patients and demonstrated infectious vegetations in four cases. Aside from antimicrobial therapy and removal of infected devices, the management of these patients included cardiac surgery (two patients), thoracoscopic surgery with decortication (one patient), and tube thoracostomy (one patient). All 14 patients recovered from their illness. CONCLUSIONS: We conclude that SPE presents with variable and often nonspecific clinical and radiographic features. The diagnosis is usually suggested by the presence of a predisposing factor, febrile illness, and CT findings of multiple, nodular lung infiltrates peripherally, with or without cavitation. This article was published in Chest and referenced in Otolaryngology: Open Access

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