Author(s): Lee HC, Ko NY, Lee NY, Chang CM, Ko WC, Lee HC, Ko NY, Lee NY, Chang CM, Ko WC
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Abstract BACKGROUND/PURPOSE: The purpose of this study was to compare the seroprevalence of viral hepatitis and sexually transmitted disease (STD) co-infections among three populations at risk recently diagnosed with HIV infection. METHODS: A retrospective review of medical records was performed to determine the prevalence of several co-infections among adults recently diagnosed with HIV infection between 2000 and 2005 at National Cheng Kung University Hospital in Tainan, Taiwan. RESULTS: Among a total of 484 adults, 124 (25.6\%) were men having sex with men (MSM), 105 (21.7\%) were heterosexual adults, and 255 (52.7\%) were injection drug users (IDUs). The case number of adults with recently diagnosed HIV infection increased annually, from 27 in 2000 to 142 in 2005 (p < 0.001). This trend appeared to be attributable to the upsurge in HIV infection among IDUs beginning in 2003. At the time of HIV diagnosis, mean CD4+ counts were significantly higher and plasma HIV-1 RNA loads were lower in the IDU group than the MSM or heterosexual groups. The hepatitis B virus (HBV) carrier rate was similar in all three groups, with an average rate of 16.5\%. The prevalence of treponemal antibody and Entamoeba histolytica indirect hemagglutination antibody was higher in MSM (37.5\% and 9.4\%, respectively) than in heterosexuals (19.6\% and 7.3\%, respectively) or IDUs (3.2\% and 2.1\%). The seroprevalence of hepatitis A virus infection increased with age, with 94.2\% (97/103) of patients who were older than 40 years. Hepatitis C virus (HCV) or HBV-HCV co-infections were noted more often in IDUs (97.9\% and 16.9\%, respectively) than in heterosexuals (10.9\% and 2.2\%, respectively) and MSM (5.3\% and 3.6\%, respectively). CONCLUSION: There was a recent upsurge in HIV-HCV co-infected IDUs in southern Taiwan. A higher rate of co-infection with STDs among HIV-infected MSM highlights the need for integrated STD control efforts in current HIV prevention programs.
This article was published in J Formos Med Assoc
and referenced in Journal of AIDS & Clinical Research