alexa Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Genetic Syndromes & Gene Therapy

Author(s): Serretti A, Calati R, Giegling I, Hartmann AM, Mller HJ,

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Abstract INTRODUCTION: Serotonin has been extensively studied in relation to both personality features and suicidal behaviours. OBJECTIVE: In this study, we considered the association between the serotonin receptor 1A (HTR1A) and 2C (HTR2C) SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI), in a sample of suicide patients and healthy volunteers. METHODS: The SNPs considered were, for HTR1A rs1423691, rs878567 and rs6295, and for HTR2C rs547536, rs2192372, rs6318, rs2428707, rs4272555 and rs1801412. The sample was composed of three groups: two German samples, consisting of a healthy control group of 289 subjects (42.6\% males, mean age: 45.2+/-14.9) and a psychiatric patient group of 111 suicide attempters (38.7\% males, mean age: 39.2+/-13.6), and an Italian sample, composed of 64 mood disorder patients (35.9\% males, mean age: 43.0+/-14.8). In the German samples all the SNPs were investigated, while in the Italian sample only the HTR1A rs6295 and the HTR2C rs6318 SNPs were considered. RESULTS: Controlling for sex, age and educational level, single markers and haplotypes were not or only marginally associated with personality dimensions. CONCLUSIONS: Our study does not support the role of HTR1A and HTR2C gene variants on personality traits in both healthy volunteers and mood disorder patients. This article was published in J Psychiatr Res and referenced in Journal of Genetic Syndromes & Gene Therapy

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