Author(s): Verre M, Bossio F, Mammone A, Piccirillo M, Tancioni F,
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Abstract We describe a case of severe serotonin syndrome. The patient was simultaneously taking the atypical antidepressant olanzapine and a tricyclical antidepressant, clomipramine. Symptoms included altered mental state resulting in coma, myoclonus, hyperreflexia, diaphoresis, diarrhoea, disorientation and fever. After suspension of antidepressant drugs, intensive symptomatic treatment and administration of biperiden and cyproheptadine, the patient's condition improved.
This article was published in Minerva Anestesiol
and referenced in Journal of Clinical Toxicology