Author(s): RosBulln MR, SnchezPedreo P, MartnezLiarte JH
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Abstract We have studied the serum ceruloplasmin levels as a possible diagnostic factor or marker for detection, diagnosis and follow-up of patients with melanoma. Ceruloplasmin concentration was determined in 64 melanoma patients (MP) and in 37 healthy persons (HP) by nephelometry. We found a mean value of 29.85 +/- 5.47 mg/dl in MP and 26.10 +/- 5.22 mg/dl in HP. A significant increase in the levels of serum ceruloplasmin was observed in MP in comparison to those in HP (P = 0.0011). In order to check whether this test could discriminate between MP and HP, a complete statistical Receiver Operating Characteristic (ROC) curve analysis was performed. The cut-off value was 25.10 mg/dl. The area under the curve was 0.689. According to these results, the test could discriminate adequately between the two groups.
This article was published in Anticancer Res
and referenced in Journal of Molecular Biomarkers & Diagnosis