alexa Serum dioxin and hepatic abnormalities in veterans of Operation Ranch Hand.


Toxicology: Open Access

Author(s): Michalek JE, Ketchum NS, Longnecker MP

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PURPOSE: We studied hepatic abnormalities and indices of hepatic function in relation to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in veterans of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of herbicides in Vietnam from 1962 to 1971.

METHODS: The prevalence of ever having liver disease through March 1993, and level of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase (GGT), lactic dehydrogenase (LDH), alkaline phosphatase, and total bilirubin were examined according to serum dioxin levels.

RESULTS: We found an increased risk of “other liver disorders” among veterans with the highest dioxin levels [adjusted odds ratio (OR) = 1.6, 95% confidence interval (CI) 1.2 to 2.1], due primarily to increased transaminases or LDH (adjusted OR = 2.7, 95% CI 1.4 to 5.1) and to other nonspecific liver abnormalities (adjusted OR = 1.4, 95% CI 1.0 to 2.0).

CONCLUSIONS: Whether the associations observed were causal is unclear from these data.

This article was published in Annals of Epidemiology and referenced in Toxicology: Open Access

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