Author(s): Mller HJ, FrikkeSchmidt R, Moestrup SK, Nordestgaard BG, TybjrgHansen A
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Abstract BACKGROUND: Activation of adipose tissue macrophages with concomitant low-grade inflammation is believed to play a central role in the development of type 2 diabetes. We tested whether a new macrophage-derived biomarker, soluble CD163 (sCD163), identifies at-risk individuals before overt disease has developed. METHODS: A prospective cohort study of 8849 study participants from the general population, the Copenhagen City Heart Study, was followed for 18 years for incidence of type 2 diabetes. Risk of disease was calculated according to age- and sex-adjusted percentile categories of serum sCD163 concentrations: 0\%-33\%, 34\%-66\%, 67\%-90\%, 91\%-95\%, and 96\%-100\%. RESULTS: A total of 568 participants developed type 2 diabetes. The cumulative incidence increased with increasing baseline sCD163 (trend P < 0.001), and sCD163 was strongly associated with known risk factors such as physical inactivity, body mass index, C-reactive protein, and triglycerides (all P < 0.001). Multifactorially adjusted hazard ratios for type 2 diabetes were 1.4 (95\% CI, 1.0-1.9), 2.4 (1.8-3.2), 3.8 (2.6-5.5), and 5.2 (3.6-7.6) for categories 34\%-66\%, 67\%-90\%, 91\%-95\%, and 96\%-100\%, respectively, vs the 0\%-33\% category. In overweight men 50-70 and >70 years of age, serum sCD163 concentrations in the top 5\% group predicted an absolute 10-year risk of type 2 diabetes of 29\% and 36\% vs 7\% and 8\% in the lowest percentile group. Equivalent values in women were 19\% and 24\% vs 4\% and 5\%. CONCLUSIONS: Increased concentrations of sCD163 predict increased risk of type 2 diabetes in the general population and may be useful for identification of high-risk overweight individuals.
This article was published in Clin Chem
and referenced in Journal of Glycomics & Lipidomics