Author(s): Scalfaro P, Chesaux JJ, Buchwalder PA, Biollaz J, Micheli JL
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Abstract Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
This article was published in Intensive Care Med
and referenced in Journal of AIDS & Clinical Research