alexa Sexual differences in sensitivity to methamphetamine toxicity.


Journal of Addiction Research & Therapy

Author(s): Wagner GC, Tekirian TL, Cheo CT

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Abstract Male and female mice were treated with methamphetamine (10.0 mg/kg/injection for four injections) and sacrificed two weeks later. It was observed that the methamphetamine treatment caused depletions in striatal dopamine which were significantly greater in males (74\%) than in females (56\%). These results indicate that estrogen may have a protective effect against methamphetamine-induced dopamine depletions and may relate to the fact that males are more likely to incur Parkinson's disease than females.
This article was published in J Neural Transm Gen Sect and referenced in Journal of Addiction Research & Therapy

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