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Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Glycomics & Lipidomics

Author(s): Georg Nickenig

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Coronary heart disease (CHD) resulting from atherosclerosis is the single largest killer in the Western world. Approximately 40% of patients with hypertension have hypercholesterolemia, which is central to the pathogenesis of atherosclerosis and cardiovascular disease (CVD).1 Conversely, hypertension is a significant risk factor in patients with elevated cholesterol.2 There is strong synergy between hypertension and hypercholesterolemia in terms of risk factors for the development of CVD.2 Both hypertension and hypercholesterolemia result in endothelial dysfunction and consequently the development of atherosclerosis. The recent definition of the metabolic syndrome, characterized by hypertension, elevated cholesterol and triglyceride levels, insulin resistance/dyslipidemia, and central obesity, has brought together these conditions with the notion that they are linked and represent a cluster of factors that are synergistic for CVD.3

This article was published in Circulation and referenced in Journal of Glycomics & Lipidomics

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