alexa Signaling cell death from the endoplasmic reticulum stress response.
Medicine

Medicine

Translational Medicine

Author(s): Shore GC, Papa FR, Oakes SA

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Abstract Inability to meet protein folding demands within the endoplasmic reticulum (ER) activates the unfolded protein response (UPR), a signaling pathway with both adaptive and apoptotic outputs. While some secretory cell types have a remarkable ability to increase protein folding capacity, their upper limits can be reached when pathological conditions overwhelm the fidelity and/or output of the secretory pathway. Irremediable 'ER stress' induces apoptosis and contributes to cell loss in several common human diseases, including type 2 diabetes and neurodegeneration. Researchers have begun to elucidate the molecular switches that determine when ER stress is too great to repair and the signals that are then sent from the UPR to execute the cell. Copyright © 2010 Elsevier Ltd. All rights reserved.
This article was published in Curr Opin Cell Biol and referenced in Translational Medicine

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