alexa Significance of isolated hepatitis B core antibody in blood donors from São Paulo.
Infectious Diseases

Infectious Diseases

Journal of Infectious Diseases & Therapy

Author(s): Almeida Neto C, Strauss E, Sabino EC, Sucupira MC, Chamone DA

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Abstract The clinical significance of isolated anti-HBc is still a challenge. To elucidate the real importance of this finding in our blood donors, an investigation algorithm was tested. One hundred and twelve isolated anti-HBc seropositive blood donors underwent clinical evaluation and retesting of HBV markers. Those who presented repeatedly reactive isolated anti-HBc, received a single dose of hepatitis B recombinant vaccine to verify anti-HBs early response. A HBV-DNA determination by PCR was done for those who did not test positive to anti-HBs after vaccine. The level of anti-HBc was recorded as a ratio of the sample-to-cut-off values (S:C ratio) in 57 candidates at donation. Comparing true and false-positive anti-HBc results, the different S:C ratios of them were statistically significant and when less than 2, implying in a false-positive result probability over 80\%. A high percent of false-positive results (16.07\%) was verified after anti-HBc retesting. HBV immunity was characterized in 49.11\%, either by anti-HBs detection in retesting (15.18\%), or after a single dose HBV vaccination (33.93\%). HBV-DNA was negative in all tested donors. In conclusion, this algorithm was useful to clarify the meaning of isolated anti-HBc in most of our blood donors.
This article was published in Rev Inst Med Trop Sao Paulo and referenced in Journal of Infectious Diseases & Therapy

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