alexa Simeprevir: a macrocyclic HCV protease inhibitor.
Medicine

Medicine

General Medicine: Open Access

Author(s): Talwani R, Heil EL, Gilliam BL, Temesgen Z

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Abstract Simeprevir is a macrocyclic NS3/4A HCV protease inhibitor with potent activity against genotypes 1, 2, 4, 5 and 6 of the hepatitis C virus (HCV). Phase II and III studies of simeprevir combined with pegylated interferon (peg-IFN) and ribavirin (RBV) demonstrated that the combination was safe and effective in HCV genotype 1 patients, with more than 75\% of treatment-naive patients attaining a sustained virological response (SVR). Simeprevir is administered once daily as a single 150-mg capsule. It has a moderate drug interaction potential, but less than that of the first-generation HCV protease inhibitors. Based on positive results from the product's phase III clinical program, simeprevir was approved and launched in Japan, the U.S. and Canada in late 2013 for use in combination with peg-IFN/RBV in HCV genotype 1 infections. Phase II interferon-free studies of simeprevir are ongoing. Copyright 2013 Prous Science, S.A.U. or its licensors. All rights reserved. This article was published in Drugs Today (Barc) and referenced in General Medicine: Open Access

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