alexa Simple and sensitive determination of nisoldipine in plasma using liquid chromatography-tandem mass spectrometry.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Kang W

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Abstract A simple and rapid quantification method was developed for determining nisoldipine in plasma. After a simple protein precipitation with a mixture of 10\% of zinc sulfate and methanol, the analytes were chromatographed on a reversed-phase C(18) column, and detected by MS/MS. The assay precision was less than 10.7\%, and the accuracy ranged from 86 to 112\%. The limit of quantification was 0.1 ng/ml. This method was used to measure the plasma concentration of nisoldipine from healthy subjects after a single 5-mg oral dose of nisoldipine.
This article was published in Anal Sci and referenced in Pharmaceutica Analytica Acta

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