alexa Simple nomograms to calculate sample size in diagnostic studies.
Immunology

Immunology

Immunotherapy: Open Access

Author(s): Carley S, Dosman S, Jones SR, Harrison M

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Abstract OBJECTIVES: To produce an easily understood and accessible tool for use by researchers in diagnostic studies. Diagnostic studies should have sample size calculations performed, but in practice, they are performed infrequently. This may be due to a reluctance on the part of researchers to use mathematical formulae. METHODS: Using a spreadsheet, we derived nomograms for calculating the number of patients required to determine the precision of a test's sensitivity or specificity. RESULTS: The nomograms could be easily used to determine the sensitivity and specificity of a test. CONCLUSIONS: In addition to being easy to use, the nomogram allows deduction of a missing parameter (number of patients, confidence intervals, prevalence, or sensitivity/specificity) if the other three are known. The nomogram can also be used retrospectively by the reader of published research as a rough estimating tool for sample size calculations.
This article was published in Emerg Med J and referenced in Immunotherapy: Open Access

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