Author(s): Csar Ida C, Andrade Nogueira FH, Antnio Pianetti G
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Abstract This paper describes the development and validation of a HPLC-UV method (210 nm) for the simultaneous quantitation of artemether and lumefantrine in fixed dose combination tablets. The method showed to be linear (r(2)>0.99), precise (R.S.D.<2.0\%), accurate (recovery of 101.07\% for artemether and 101.58\% for lumefantrine), specific and robust. Four batches of artemether-lumefantrine tablets were assayed by the validated method. The artemether contents in the tablets varied from 98.61\% to 103.35\%, while lumefantrine contents were 97.92-100.48\%.
This article was published in J Pharm Biomed Anal
and referenced in International Journal of Biomedical Data Mining