alexa Simultaneous Estimation of Metformin and Sitagliptin In Tablet Dosage For
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Ghazala Khan, Dinesh Sahu, Y P Agrawal, Neetu Sabarwal, Avnish Jain

Abstract Share this page

A simple, precise and highly selective analytical method was developed for simultaneous estimation of Metformin HCl and Sitagliptin in tablet formulation. Estimation was carried out by multi-component mode of analysis at selected wavelength of 232 nm and 267 nm for Metformin HCl and Sitagliptin respectively in distilled water. The method was found to be linear in the range of 1-40 μg/ml and accuracy of the method was confirmed by recovery studies of tablet dosages forms and was found to be 99.35% and 98.33% for Metformin HCl and Sitagliptin respectively. Initially lab samples were utilized to validate developed method according to ICH guidelines followed by determination of % concentration of Metformin HCl and Sitagliptin in marketed formulation that was found to be 98.26% ± 0.29 and 97.35% ± 1.38 respectively. The values of precision and robustness lie within acceptable limit. Thus the proposed method can be successfully applied for simultaneous determination of Metformin HCl and Sitagliptin in routine analytical work

  • To read the full article Visit
  • Open Access
This article was published in Asian Journal of Biochemical and Pharmaceutical Research and referenced in Journal of Chromatography & Separation Techniques

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords