alexa Simultaneous Estimation of Metformin and Sitagliptin In Tablet Dosage For
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Ghazala Khan, Dinesh Sahu, Y P Agrawal, Neetu Sabarwal, Avnish Jain

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A simple, precise and highly selective analytical method was developed for simultaneous estimation of Metformin HCl and Sitagliptin in tablet formulation. Estimation was carried out by multi-component mode of analysis at selected wavelength of 232 nm and 267 nm for Metformin HCl and Sitagliptin respectively in distilled water. The method was found to be linear in the range of 1-40 μg/ml and accuracy of the method was confirmed by recovery studies of tablet dosages forms and was found to be 99.35% and 98.33% for Metformin HCl and Sitagliptin respectively. Initially lab samples were utilized to validate developed method according to ICH guidelines followed by determination of % concentration of Metformin HCl and Sitagliptin in marketed formulation that was found to be 98.26% ± 0.29 and 97.35% ± 1.38 respectively. The values of precision and robustness lie within acceptable limit. Thus the proposed method can be successfully applied for simultaneous determination of Metformin HCl and Sitagliptin in routine analytical work

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This article was published in Asian Journal of Biochemical and Pharmaceutical Research and referenced in Journal of Chromatography & Separation Techniques

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