alexa Sirtuin 1 and aging theory for chronic obstructive pulmonary disease.
Healthcare

Healthcare

Journal of Community Medicine & Health Education

Author(s): Conti V, Corbi G, Manzo V, Pelaia G, Filippelli A, , Conti V, Corbi G, Manzo V, Pelaia G, Filippelli A, , Conti V, Corbi G, Manzo V, Pelaia G, Filippelli A, , Conti V, Corbi G, Manzo V, Pelaia G, Filippelli A,

Abstract Share this page

Abstract Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus, there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets. Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD. Recently it was suggested that Sirtuin 1 (SIRT1), an antiaging molecule involved in the response to oxidative stress and chronic inflammation, is implicated in both development and progression of COPD. The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes. Recent evidence corroborating the statement of the "aging theory for COPD" was also discussed.
This article was published in Anal Cell Pathol (Amst) and referenced in Journal of Community Medicine & Health Education

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords