alexa Six-minute walk distance in persons with Parkinson disease: a hierarchical regression model.
General Science

General Science

Journal of Biomusical Engineering

Author(s): Falvo MJ, Earhart GM

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Abstract OBJECTIVES: To determine the six-minute walk distance (6MWD) in subjects with Parkinson disease (PD) and to determine the impairments that contribute to walking capacity. DESIGN: Descriptive cross-sectional study of subjects with PD. SETTING: University laboratory. PARTICIPANTS: Subjects with PD (N=75; 65.0+/-9.5y) of mild to moderate severity, as defined by an average Hoehn and Yahr (HY) rating of 2.0+/-0.4 and Unified Parkinson Disease Rating Scale (UPDRS) motor score of 27+/-8.9, were tested on medication. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Subjects were administered the motor subsection of the UPDRS and completed the following tests: Berg Balance Scale (BBS), Timed Up & Go (TUG), and six-minute walk test. In addition, they also provided self-reports of freezing of gait and number of falls in the past 6 months. RESULTS: The average 6MWD was 391.6+/-99.9 m. All of the aforementioned tests, with the exception of fall number (P=.07), correlated significantly with 6MWD (r range, -.64 to .55). By using a hierarchical regression model, we entered age, HY, and UPDRS motor score into the first block (ie, set of independent variables) to represent parkinsonian characteristics, which explained a significant amount of variability in 6MWD (R2=.196, P<.001). The second block entered (eg, functional measures scores, self-reports) explained a significant amount of additional variability (R2 change=.355, P<.001). The TUG, BBS, and number of falls contributed independently in the presence of all independent variables. CONCLUSIONS: The 6MWD in subjects with PD is explained in part by disease-specific characteristics and perhaps to a greater extent by impaired balance and predisposition to falling. Training targeted at improving balance and reducing falling risk factors may increase 6MWD (ie, walking capacity) in subjects with PD. This article was published in Arch Phys Med Rehabil and referenced in Journal of Biomusical Engineering

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