alexa Size, concentration and incubation time dependence of gold nanoparticle uptake into pancreas cancer cells and its future application to X-Ray Drug Delivery System.
Microbiology

Microbiology

Journal of Bacteriology & Parasitology

Author(s): Trono JD, Mizuno K, Yusa N, Matsukawa T, Yokoyama K, , Trono JD, Mizuno K, Yusa N, Matsukawa T, Yokoyama K, , Trono JD, Mizuno K, Yusa N, Matsukawa T, Yokoyama K, , Trono JD, Mizuno K, Yusa N, Matsukawa T, Yokoyama K,

Abstract Share this page

Abstract One of the restrictions in the potential use of gold markers for medical imaging/tracking of harder tumors is its size. We propose to use gold nanoparticles which, due to its small size, can be administered conveniently via intravenous injection. One of the factors that determine the clinical utility of nanoparticles is the ability to enter cells. In this report, the stability of gold nanoparticles mixed with different media was determined by UV-vis spectroscopy. Gold nanoparticle size was confirmed by TEM. Intracellular uptake using different gold nanoparticle sizes, incubation times and concentrations were analyzed using Atomic Absorption Spectrometry (AAS). Temperature dependence uptake was also measured using AAS. The results showed that pancreas cancer cells uptake 20 nm gold nanoparticles preferentially compared to other gold nanoparticle sizes. Efficient accumulation of gold nanoparticles into pancreas cancer cells can be achieved at longer incubation time and higher concentration. The findings of this study will help in the design and optimization of the gold nanoparticle-based agents for therapeutic and diagnostic applications of X-ray Drug Delivery System.
This article was published in J Radiat Res and referenced in Journal of Bacteriology & Parasitology

Relevant Expert PPTs

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords