alexa Skeletal muscle characteristics of people with multiple sclerosis.
Neurology

Neurology

Journal of Multiple Sclerosis

Author(s): Carroll CC, Gallagher PM, Seidle ME, Trappe SW

Abstract Share this page

Abstract OBJECTIVE: To compare the single-fiber characteristics and muscle weakness of persons with multiple sclerosis (MS) with that of healthy persons without MS. DESIGN: Descriptive. SETTING: A university-based exercise physiology laboratory. PARTICIPANTS: Fourteen subjects (7 controls, 7 people with relapsing-remitting MS; Expanded Disability Status Scale median score, 6.0; range, 2.5-6.5). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Singe muscle fiber myosin heavy chain (MHC) distribution, myosin adenosine triphosphatase fiber type, and single muscle fiber cross-sectional area (CSA). RESULTS: The distribution of MHC I, MHC IIa, MHC IIx, and total hybrid fibers (I/IIa+I/IIa/IIx+IIa/IIx) did not differ between the 2 groups. However, the distribution of MHC I/IIa/IIx fibers was greater ( P <.040) in the MS group (MS: 6\% vs controls: 2\%). MS subjects also had a greater proportion ( P <.002) of MHC IIx-dominant IIa/IIx fibers (MS: 46\% vs controls: 13\%). Single-fiber CSA and fiber type, for all fiber types, did not differ between groups. CONCLUSIONS: These data suggest that, in general, moderately impaired MS subjects with documented muscle weakness have similar MHC and fiber-type characteristics as age-matched sedentary controls. The data indicate that the quality of skeletal muscle, with regard to MHC distribution, is unaffected by MS. This article was published in Arch Phys Med Rehabil and referenced in Journal of Multiple Sclerosis

Relevant Expert PPTs

Relevant Speaker PPTs

  • Ildiko Molnar
    The role of tissue-specific type 2 5’-deiodinase enzyme activities in Graves’ orbitopathy and systemic sclerosis: a new candidate in thyroid autoimmunity
    PDF Version
  • Sergey Suchkov
    Translational tools as applicable to autoimmune disorders: antibody-proteases as a generation of highly informative and unique biomarkers to monitor subclinical and clinical stages of demyelination in multiple sclerosis (MS)
    PPT Version | PDF Version
  • Miriam Furst-Yust
    Miriam-Furst-Tel-Aviv-University-Israel-The-correlation-between-binaural-perception-and-brain-stem-lesions
    PPT Version | PDF Version
  • Ahmed G Hegazi
    Cytokines pattern of multiple sclerosis patients treated with Apitherapy
    PPT Version | PDF Version

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords