alexa Skin sealant InteguSeal® has no impact on prevention of postoperative mediastinitis after cardiac surgery.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Waldow T, Szlapka M, Hensel J, Pltze K, Matschke K,

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Abstract BACKGROUND: Surgical site infections (SSIs) after median sternotomy represent a serious complication and a high potential risk for adverse clinical outcome after cardiac surgery. The antimicrobial skin sealant InteguSeal® was introduced as a novel tool in preventing development of SSI. AIM: This single-centre investigation used two prospective registries to evaluate the prophylactic effect of a cyanoacrylate-based antimicrobial skin sealant (InteguSeal®) on the incidence of postoperative mediastinitis or any other form of chest skin incision SSI after elective cardiac surgery. METHODS: Between October 2010 and April 2011 a total of 998 patients underwent elective cardiac surgical procedures with median sternotomy in our centre. In 496 patients InteguSeal® was included in standard preoperative preparation procedures before chest skin incision (group 1). In 502 patients standard preoperative skin preparation procedures were used without InteguSeal® (group 2). Freedom from mediastinitis and from any other form of SSI within 30 postoperative days were the primary and secondary endpoints, respectively. FINDINGS: A total of 983 patients were eligible for inclusion in per-protocol analysis (488 vs 495 patients). The incidence of postoperative mediastinitis was 2.3\% in group 1 vs 3.2\% in group 2 (not significant). The incidence of any form of SSI was 10.9\% in group 1 vs 11.5\% in group 2 (not significant). Perioperative patient characteristics, complexity of surgical procedures performed and length of hospitalization were similar in both groups. CONCLUSION: The use of InteguSeal® has no influence on the incidence of postoperative SSI and mediastinitis after cardiac surgery with median sternotomy. Copyright © 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. This article was published in J Hosp Infect and referenced in Journal of Addiction Research & Therapy

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