alexa SLC transporters as therapeutic targets: emerging opportunities.
Materials Science

Materials Science

Journal of Nanomedicine & Biotherapeutic Discovery

Author(s): Lin L, Yee SW, Kim RB, Giacomini KM

Abstract Share this page

Abstract Solute carrier (SLC) transporters - a family of more than 300 membrane-bound proteins that facilitate the transport of a wide array of substrates across biological membranes - have important roles in physiological processes ranging from the cellular uptake of nutrients to the absorption of drugs and other xenobiotics. Several classes of marketed drugs target well-known SLC transporters, such as neurotransmitter transporters, and human genetic studies have provided powerful insight into the roles of more-recently characterized SLC transporters in both rare and common diseases, indicating a wealth of new therapeutic opportunities. This Review summarizes knowledge on the roles of SLC transporters in human disease, describes strategies to target such transporters, and highlights current and investigational drugs that modulate SLC transporters, as well as promising drug targets.
This article was published in Nat Rev Drug Discov and referenced in Journal of Nanomedicine & Biotherapeutic Discovery

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • World Congress on Regulations of Nanotechnology
    July 31-August 01, 2017 Chicago, Illinois, USA
  • 19th Nano Congress for Next Generation
    August 31-September 01, 2017 Brussels,Belgium
  • International conference on Industrial Nanotechnology
    September 18-19, 2017 Jacksonville, Florida, USA
  • 15th World Medical Nanotechnology Congress & Expo
    October 18-19, 2017 Osaka, Japan
  • 22ndInternational Conference and Expo on Nanoscience and Molecular Nanotechnology
    Nov 13-14, 2017 Vienna, Austria
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version