alexa Sleep drives metabolite clearance from the adult brain.
Mathematics

Mathematics

Journal of Applied & Computational Mathematics

Author(s): Xie L, Kang H, Xu Q, Chen MJ, Liao Y,

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Abstract The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60\% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.
This article was published in Science and referenced in Journal of Applied & Computational Mathematics

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