alexa Small, dense HDL particles exert potent protection of atherogenic LDL against oxidative stress.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Glycomics & Lipidomics

Author(s): Kontush A, Chantepie S, Chapman MJ

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Abstract OBJECTIVE: The relationship of the structural and functional heterogeneity of HDL particles to protection of LDL against oxidative stress is indeterminate. METHODS AND RESULTS: HDL subfractions of defined physicochemical properties were isolated by density gradient ultracentrifugation from normolipidemic human serum (n=8), and their capacity to protect LDL from oxidation was evaluated. Under mild oxidative stress induced by AAPH or Cu(II), HDL subfractions (at equal cholesterol or protein concentration or equal particle number) significantly decreased LDL oxidation rate (-20\% to -85\%) in the propagation phase (234 nm), which was prolonged by up to 82\% with decreased maximal diene formation. Antioxidative activity of HDL subfractions increased with increment in density, as follows: HDL2b
  • DOI: 10.1161/01.ATV.0000091338.93223.
  • This article was published in Arterioscler Thromb Vasc Biol and referenced in Journal of Glycomics & Lipidomics

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