alexa Smart hydrogel particles: biomarker harvesting: one-step affinity purification, size exclusion, and protection against degradation.
Physicaltherapy & Rehabilitation

Physicaltherapy & Rehabilitation

Journal of Sports Medicine & Doping Studies

Author(s): Luchini A, Geho DH, Bishop B, Tran D, Xia C,

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Abstract Disease-associated blood biomarkers exist in exceedingly low concentrations within complex mixtures of high-abundance proteins such as albumin. We have introduced an affinity bait molecule into N-isopropylacrylamide to produce a particle that will perform three independent functions within minutes, in one step, in solution: (a) molecular size sieving, (b) affinity capture of all solution-phase target molecules, and (c) complete protection of harvested proteins from enzymatic degradation. The captured analytes can be readily electroeluted for analysis.
This article was published in Nano Lett and referenced in Journal of Sports Medicine & Doping Studies

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