alexa Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis.
Cardiology

Cardiology

Cardiovascular Therapy: Open Access

Author(s): Klareskog L, Malmstrm V, Lundberg K, Padyukov L, Alfredsson L, Klareskog L, Malmstrm V, Lundberg K, Padyukov L, Alfredsson L

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Abstract This review describes how studies on interactions between genetic variants, and environmental factors, mainly smoking, contribute to the understanding of how autoimmunity to post-translationally (citrullinated) proteins/peptides may occur and potentially contribute to certain subsets of rheumatoid arthritis. A main message is that studies on specific immune mechanisms in a complex and heterogeneous disease like RA should be undertaken with the help of results from genetic epidemiology. By those means, it may be possible to identify subsets of RA in a way that in the end allows development and testing of precise and subset-specific interventions against environment as well as genetically defined molecular pathways, in particular those that regulate specific immune responses. Copyright © 2011. Published by Elsevier Ltd. This article was published in Semin Immunol and referenced in Cardiovascular Therapy: Open Access

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