Author(s): Leyba L, Mayer AR, Gollub RL, Andreasen NC, Clark VP
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Abstract BACKGROUND: Functional magnetic resonance imaging (FMRI) studies comparing schizophrenia patients and controls may have been confounded by the vascular effects of heavier long-term cigarette use in patients. METHODS: The blood oxygen level dependent (BOLD) response to a simple sensorimotor task was compared between schizophrenia patient with a smoking history (mean 17 pack years) and carefully matched patient non-smokers and control non-smokers. RESULTS: Group differences in activation magnitude and spatial extent were non-significant. CONCLUSIONS: Typical smoking histories in schizophrenia patients do not significantly confound FMRI results in simple sensorimotor tasks when patient demographics are carefully controlled.
This article was published in Schizophr Res
and referenced in Journal of Addiction Research & Therapy