alexa S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
Ophthalmology

Ophthalmology

Journal of Clinical & Experimental Ophthalmology

Author(s): Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M

Abstract Share this page

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) influences cytotoxicity, translocating to the nucleus during apoptosis. Here we report a signalling pathway in which nitric oxide (NO) generation that follows apoptotic stimulation elicits S-nitrosylation of GAPDH, which triggers binding to Siah1 (an E3 ubiquitin ligase), nuclear translocation and apoptosis. S-nitrosylation of GAPDH augments its binding to Siah1, whose nuclear localization signal mediates translocation of GAPDH. GAPDH stabilizes Siah1, facilitating its degradation of nuclear proteins. Activation of macrophages by endotoxin and of neurons by glutamate elicits GAPDH–Siah1 binding, nuclear translocation and apoptosis, which are prevented by NO deletion. The NO–S-nitrosylation–GAPDH–Siah1 cascade may represent an important molecular mechanism of cytotoxicity.

This article was published in Nature Cell Biology and referenced in Journal of Clinical & Experimental Ophthalmology

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