alexa Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration.
Social & Political Sciences

Social & Political Sciences

Journal of Civil & Legal Sciences

Author(s): Morgan D, Grant KA, Gage HD, Mach RH, Kaplan JR,

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Abstract Disruption of the dopaminergic system has been implicated in the etiology of many pathological conditions, including drug addiction. Here we used positron emission tomography (PET) imaging to study brain dopaminergic function in individually housed and in socially housed cynomolgus macaques (n = 20). Whereas the monkeys did not differ during individual housing, social housing increased the amount or availability of dopamine D2 receptors in dominant monkeys and produced no change in subordinate monkeys. These neurobiological changes had an important behavioral influence as demonstrated by the finding that cocaine functioned as a reinforcer in subordinate but not dominant monkeys. These data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction. This article was published in Nat Neurosci and referenced in Journal of Civil & Legal Sciences

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