alexa Social stress in laboratory rats: hormonal responses and immune cell distribution.
Medicine

Medicine

Anatomy & Physiology: Current Research

Author(s): Stefanski V

Abstract Share this page

Abstract Previous experiments with chronically coexisting groups of Long-Evans rats indicated differences in many aspects of blood cellular immunity between winner and loser rats. The present study investigated the specific hormonal response patterns of winners and losers in relation to changes in numbers of blood immune cells. At the beginning of a 7 day period of chronic confrontation, a partition wall was removed between two neighboring rat groups, each containing a male-female pair. Fights for dominance between the males resulted in fast establishment of stable dominance relationships. At day 7 of the confrontation, winner males showed stable concentrations of CBG (corticosteroid-binding globulin) and even reduced titers of total CORT (corticosterone). In contrast, a marked decrease in CBG and unaffected total CORT concentrations were determined in loser males. Increased norepinephrine (NE) and epinephrine (E) titers were evident only in losers. In addition, reduced testosterone titers were observed in the bitten loser male subgroup. All male subgroups lost body mass with most pronounced reductions in loser males. Confrontation caused a marked granulocytosis, especially in loser males. NE concentrations in loser males correlated with the percentage of granulocytes. Numbers of CD4 T-cells were lowered in all loser males and in non-biting winners. In not-bitten losers also a reduced number of CD8 T-cells was determined. Interestingly, higher pre-confrontational NE titers were detected in future bitten loser and future biting winner males relatively to not-bitten losers and non-biting winners. The present report indicates that differential hormonal response patterns may play an important role in some of the immunological differences observed between winner and loser males under stressful social conditions.
This article was published in Psychoneuroendocrinology and referenced in Anatomy & Physiology: Current Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • International Human Anatomy and Physiology Congress
    November 2-3, 2017 Atlanta, USA

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords