alexa Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options


Journal of Antivirals & Antiretrovirals

Author(s): Jacobson IM

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The combination of peginterferon and ribavirin is considered a standard of therapy for patients chronically infected with either genotype 2 or 3 hepatitis C virus (HCV). This regimen is associated with high rates of sustained virologic response (SVR) in both untreated and previously treated patients (70%-85% and 55%-60% response rates in each group, respectively).1-4 However, there is currently a major gap in the field of hepatitis treatment of patients with HCV genotype 2 or 3 who are either unable to be treated with peginterferon or who previously failed to have a response to peginterferon. The number of patients affected by this is not insignificant; one report estimated that this patient group comprises the majority of HCV-infected patients.4 Thus, treatment alternatives are needed for chronically HCV-infected patients who are either unable to be treated with peginterferon or who previously failed to have a response to peginterferon. One potential treatment is the oral nucleotide analogue sofosbuvir. In vitro studies show that sofosbuvir is active across all HCV genotypes.5 A phase 2 trial in patients with chronic HCV infection (either genotype 2 or 3) found that treatment with sofosbuvir plus ribavirin resulted in a SVR in 100% (10 of 10) of previously untreated patients and 68% (17 of 25) of previously treated patients.6,7 Based on this, 2 phase 3 trials were designed to evaluate sofosbuvir plus ribavirin specifically in genotype 2 or 3 HCV-infected patients in whom either peginterferon therapy was not an option or who had previously failed to respond to peginterferon.8

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This article was published in Gastroenterol Hepatol and referenced in Journal of Antivirals & Antiretrovirals

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