alexa Soft, Fuzzy, and Bioactive Conducting Polymers for Improving the Chronic Performance of Neural Prosthetic Devices.


Journal of Aeronautics & Aerospace Engineering

Author(s): Authors Kim DH, RichardsonBurns S, Povlich L, Abidian MR, Spanninga S,

Abstract Share this page

Excerpt Microfabricated electrodes for stimulating and recording signals from individual neurons have facilitated direct electrical connections with living tissue. While these devices have worked reasonably well in acute applications, chronically implanted electrodes have had more limited success [1,2]. To improve the long-term integration of these devices, coatings have been developed to accommodate the differences in mechanical properties, bioactivity, and mechanisms of charge transport between the engineered electronic device and living cells [3–10]. Conducting polymers can be directly deposited onto electrode surfaces with precisely controlled morphologies. The coatings lower the impedance of the electrodes and provide a mechanical buffer between the hard device and the soft tissue. These coatings can be tailored to incorporate and deliver pharmacological agents such as anti-inflammatory drugs and neurotrophic factors. In vivo studies to date have shown that these coatings improve the long-term recording performance of cortical electrodes [11]. In this review we first discuss the development of neural prosthetic devices, including the history of their development, issues associated with the electrode–tissue interface, inflammation and neural loss in the tissue near the electrode surface, the mechanical property differences between the probe and the tissue, the geometry of the probe, and materials used to modify the electrode surface. We then discuss the design of materials for the electrode–tissue interface to help these probes function more effectively over the long term. These materials are intended to improve device performance by creating a mechanically compliant (soft), high-surface-area (fuzzy), low-impedance electrode–tissue interface that can have controlled biological functionality. We conclude by describing the results of work to date that have focused on the design, synthesis, and characterization of electrode interface materials, with particular attention to the use of conducting polymers that have been shown to significantly improve the electrical properties at these interfaces. Copyright © 2008, Taylor & Francis Group, LLC.
This article was published in Soft, Fuzzy, and Bioactive Conducting Polymers for Improving the Chronic Performance of Neural Prosthetic Devices and referenced in Journal of Aeronautics & Aerospace Engineering

Relevant Expert PPTs

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version