alexa Solar elastosis and presence of mast cells as key features in the pathogenesis of melasma.


Dermatology and Dermatologic Diseases

Author(s): HernndezBarrera R, TorresAlvarez B, CastanedoCazares JP, OrosOvalle C, Moncada B, HernndezBarrera R, TorresAlvarez B, CastanedoCazares JP, OrosOvalle C, Moncada B

Abstract Share this page

Abstract Melasma is an acquired hypermelanosis on sun-exposed areas. Its pathogenesis has not been clearly elucidated. Using histochemistry (Giemsa, Verhoeff-van Gieson and Fontana-Masson staining), we evaluated melasma lesions and compared them with nonlesional skin. Skin samples were obtained from lesional and nonlesional facial skin of 27 patients with melasma, and biopsies were also taken from normal control subjects. Mast cells and solar elastosis areas were evaluated using a computer-assisted image-analysis program. Lesional skin had abundant elastotic material compared with nonaffected skin (13.3 +/- 2.8\% vs. 10.2 +/- 2.9\%, P < 0.001). Mast cells were more prominent in the elastotic areas of melasma skin (173 +/- 57\% vs. 145 +/- 57\%, P = 0.04). Melasma could be a result of a cumulative sun exposure, in a microenvironment of cutaneous photoageing in which inflammatory cells, particularly mast cells, play a key role. This article was published in Clin Exp Dermatol and referenced in Dermatology and Dermatologic Diseases

Relevant Expert PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version