alexa Solid phase extraction and HPLC analysis of toxic components eluted from methyl methacrylate dental materials.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Shintani H, Tsuchiya T, Hata Y, Nakamura A

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Abstract Methyl methacrylate polymer (PolyMMA) is widely used as the composite resin for the dental plate. During the fabrication process of PolyMMA for the polymerization reaction, benzoylperoxide (BPO) and N,N-dimethyl p-toluidine (DMPT) are added as the initiator and the stimulator, respectively. Because these compounds exhibit toxicity as well as a residue potential, their use raises concerns regarding human safety. The degree of dissolution into serum was determined to evaluate risk to the user. Analysis was by HPLC combined with solid-phase extraction using a C-18 column. The eluted compounds were found to be in the order of 10 to 100 ppm.
This article was published in J Anal Toxicol and referenced in Pharmaceutica Analytica Acta

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