alexa Solid-Phase Extraction (SPE) Techniques for Sample Preparation in Clinical and Pharmaceutical Analysis: A Brief Overview
Chemical Engineering

Chemical Engineering

Journal of Analytical & Bioanalytical Techniques

Author(s): Li Kong M, Rivory Laurent P, Clarke Stephen J

Abstract Share this page

Quantitation of low concentration of drugs, metabolites and endogenous compounds in plasma has always been a difficulty and challenge task for analytical chemists in biomedical and pharmaceutical analysis. It often requires extracting and concentrating the analytes in the samples for quantitative analysis. Extraction from the plasma matrix potentially enables the simultaneous removal of endogenous interfering substances and the enrichment of the analytes. However, extraction procedures are frequently the most time consuming steps of the analytical process. Lack of robustness of the extraction procedure is a common problem leading to the invalidation of entire analytic runs. Solid- Phase Extraction (SPE) is a powerful sample preparation technique currently available for rapid clean-up and enrichment of sample analytes preceding chromatographic analysis. Compared to traditional liquid-liquid extraction (LLE), SPE provides major advantages in terms of simplicity, high throughput, robustness, and in most cases, greater cost effectiveness. A wide range of SPE resin chemistries is now available for various applications. The sampling format has also extended from simple packed disposable syringes to cartridges, disks, SPE pipette tips, 96-well and 384-well microplates. Therefore, SPE sample preparation techniques provide improved assay standardisation and hence better reproducibility. The objective of this article was to review literatures regarding SPE extraction theory, extraction modes and its application in clinical and pharmaceutical analysis. Updated information about the most important features of the SPE materials and the future trends in SPE sample preparation are also discussed.

This article was published in Current Pharmaceutical Analysis and referenced in Journal of Analytical & Bioanalytical Techniques

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords