alexa Solitary giant xanthogranuloma and benign cephalic histiocytosis--variants of juvenile xanthogranuloma.


Journal of Clinical & Experimental Dermatology Research

Author(s): Zelger BG, Zelger B, Steiner H, Mikuz G

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Abstract Sequential biopsies taken from a patient with a solitary giant xanthogranuloma, an exaggerated macronodular (> 5 cm in diameter) variant of juvenile xanthogranuloma, and from a patient with benign cephalic histiocytosis, revealed a characteristic time sequence of histopathological findings. Early stages of the diseases showed a monomorphous infiltrate of mononuclear vacuolated histiocytes positive for KiM1p, HAM56 and factor XIIIa and were characterized by clusters of comma-shaped bodies. This was followed by a polymorphous mixture of various mononuclear and multinucleate histiocytes additionally labelling with KP1 (CD68) and, in occasional cells, for the adherence of peanut agglutinin. A variety of ultrastructural changes were found, including dense and regularly laminated bodies or lipid droplets. Our findings indicate that both entities are variants of a xanthogranulomatous reaction.
This article was published in Br J Dermatol and referenced in Journal of Clinical & Experimental Dermatology Research

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