Author(s): ogesh S Thorat, I ndrajeet D Go njari
Most of t he drugs in the developmental pipeline are emerging from the High - Throughput Screening methodology resulting in increased molecular weights and thus consequential bioavailability problems. The bioavailability issue can be due to insufficient solubility of permeability. Most compounds face the solubility problems. Hence, with the advancement of chemical science, the need of development of pharmaceutical technologies is also increasing. Pharmaceutical approaches to correct the bioavailability are definitely b eing cost - effective in comparison with chemical approaches which are also time - consuming. Hence various methods of solubility enhancement are being developed. Each technique is with several merits and demerits. To tackle the disadvantages of conventional a pproaches, newer techniques are developed by many researchers. In this review, an attempt of comparing the conventional and novel techniques is done .