alexa Solubility, stability and ionization behaviour of famotidine.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmacovigilance

Author(s): Islam MS, Narurkar MM

Abstract Share this page

Abstract The pKa of famotidine was determined at 23 +/- 0.2 degrees C to be 6.76, 6.98 and 6.89 by a spectrophotometric, solubility, and partitioning method, respectively. The pH-solubility profile of famotidine indicated an intrinsic solubility of 2.7 mM at 23 degrees C. Degradation of famotidine followed pseudo-first-order kinetics over a pH range of 1-11 at 37 +/- 0.2 degrees C and at an ionic strength (mu) of 0.5. The pH-rate profile was accounted for by the specific acid and base catalysed reactions as well as water-catalysed decomposition of both protonated and free famotidine. A pKa of 6.60, determined by potentiometry at 37 +/- 0.5 degrees C (mu = 0.5), was used in the kinetic calculations. Maximum stability occurred at pH 6.3. Undissociated acetic acid, dihydrogen phosphate ion and glycine anion were found to contribute to the general acid and base catalyses. pH-dependency of the apparent octanol-water partition coefficient of famotidine indicated a partition coefficient of 0.23 for free famotidine at 23 +/- 0.2 degrees C.
This article was published in J Pharm Pharmacol and referenced in Journal of Pharmacovigilance

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords