alexa Soluble CD14 is a nonspecific marker of monocyte activation.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): Shive CL

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Soluble CD14 is associated with morbidity and mortality in HIV disease. It is a co-receptor for lipopolysaccharide (LPS) that is released from monocytes upon activation. We demonstrate here, that inflammatory cytokines can induce the release of sCD14 in peripheral blood mononuclear cell cultures from healthy donors, and that TLR ligands other than LPS can cause a decrease in the monocyte cell surface expression of CD14. Thus, sCD14 is a marker of monocyte activation, not restricted to activation by LPS.

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This article was published in AIDS and referenced in Journal of Antivirals & Antiretrovirals

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