alexa Solution structure by nuclear magnetic resonance of the two lantibiotics 97518 and NAI-107.


Fermentation Technology

Author(s): Vasile F, Potenza D, Marsiglia B, Maffioli S, Donadio S

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Abstract Lantibiotics 97518 and NAI-107, produced by the related genera Planomonospora and Microbispora respectively, are members of a family of nisin-related compounds. They represent promising compounds to treat infections caused by multiresistant Gram-positive pathogens. Despite their similar structure and a similar antibacterial spectrum, the two lantibiotics exhibit significant differences in their potency. To gain an insight into the structure-activity relationships, their conformational properties in solution are determined by NMR. After carrying out an NOE analysis of 2D (1)H NMR spectra, high-resolution 3D structures are determined using molecular dynamics simulations. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd. This article was published in J Pept Sci and referenced in Fermentation Technology

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