Author(s): Metzler WJ, Bajorath J, Fenderson W, Shaw SY, Constantine KL,
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Abstract The structure of human CTLA-4 reveals that residues Met 99, Tyr 100 and Tyr 104 of the M99YPPPY104 motif are adjacent to a patch of charged surface residues on the A'GFCC' face of the protein. Mutation of these residues, which are conserved in the CTLA-4/CD28 family, significantly reduces binding to CD80 and/or CD86, implicating this patch as a ligand binding site.
This article was published in Nat Struct Biol
and referenced in Journal of Clinical & Cellular Immunology