alexa Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: an immunofluorescence study.
Oncology

Oncology

Chemotherapy: Open Access

Author(s): Giannoccaro MP, Donadio V, Gomis Prez C, Borsini W, Di Stasi V,

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Abstract Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment. This article was published in Neurol Sci and referenced in Chemotherapy: Open Access

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